35. Design and anticancer properties of new water-soluble ruthenium-cyclopentadienyl complexes

 Tânia S. Morais*, Fernanda Marques, Paulo J. Amorim Madeira, Maria Paula Robalo, Maria Helena Garcia 

Pharmaceuticals , 2022, 15(7), 862. DOI: 10.3390/ph15070862

34. Broad spectrum functional activity of structurally related monoanionic Au(III) bis(dithiolene) complexes

Yann Le Gal, Agathe Filatre-Furcate, O. Jeannin; Thierry Roisnel, Vincent Dorcet, Diana Fontinha, Denise Francisco, Miguel Prudêncio, Marta Martins, Catarina Soeiro, Sílvia A. Sousa, Jorge H. Leitão, Tânia S. Morais, Inês Bártolo, Nuno Taveira, Joana F. Guerreiro, Fernanda Marques, Dominique Marie Lorcy  

Dalton Trans., 2022, 51, 2593-2609. DOI: 10.3390/ijms23137146

33. Are smart delivery systems the solution to overcome the lack of selectivity of current metallodrugs in cancer therapy?

 João Franco Machado,  Tânia S. Morais*

Int. J. Mol. Sci., 2022, 23(13), 7146. DOI: 10.1039/D1DT04079K


26. New copper(I) complexes selective for prostate cancer cells

João Franco Machado, Diogo A. Sequeira, Fernanda M. Marques, Maria Fátima Minas da Piedade, Maria Villa Brito, Maria Helena Garcia, Alexandra R Fernandes, Tânia S. Morais*

Dalton Trans., 2020, 49, 12273-12286. DOI:10.1039/D0DT02157A

25. Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective antitumor, antimicrobial and antiplasmodial agentes

Diana Fontinha, Sílvia A. Sousa, Tânia S. Morais, Miguel Prudêncio, Jorge H. Leitão, Yann Le Gal, Dominique Lorcy, Marta M. Andrade, Mariana F.G. Velho, M. Almeida, Dulce Belo, Joana F. Guerreiro, Rafaela A. L. Silva, Teresa Pinheiro, Fernanda Marques

Metallomics, 2020, 12, 974-987. DOI: 10.1039/D0MT00064G.

24. Novel “ruthenium cyclopentadienyl”-peptide conjugate complexes against human FGFR(+) breast cancer

João Franco Machado, Miguel Machuqueiro, Fernanda M. Marques, Maria Paula Alves Robalo, Maria Fátima Minas da Piedade, Maria Helena Garcia, João D. G. Correia, Tânia S. Morais*,

Dalton Trans., 2020, 49, 5974-5987. DOI: 10.1039/D0DT00955E  


32. Ultrasonication Improves Solid Phase Synthesis of Peptides Specific for Fibroblast Growth Factor Receptor and for the Protein-Protein Interface RANK-TRAF6

Rúben D. M. Silva, João Franco Machado, Kyle Gonçalves, Francisco M. Lucas, Salete Batista, Rita Melo, Tânia S. Morais*, João D. G. Correia

Molecules, 2021, 26(23), 7349. DOI: 10.3390/molecules26237349


31. Gold(I) Bis(1,2,3-triazol-5-ylidene) Complexes as Promising Selective Anticancer Compounds

Jonas F. Schlagintweit, Christian H. G. Jakob, Nicola L. Wilke, Marie Ahrweiler, Corazon Frias, Jerico Frias, Marcel König, Eva-Maria H. J. Esslinger, Fernanda Marques, João F. Machado, Robert M. Reich, Tânia S. Morais, João D. G. Correia, Aram Prokop, Fritz E. Kühn

J. Med. Chem., 2021, 64(21), 15747. DOI: 10.1021/acs.jmedchem.1c01021

30. Binding of RuCp complexes with human apo-transferrin: fluorescence spectroscopy and molecular docking methods

Filipa C. Santos, Paulo J. Costa, M. Helena Garcia, Tânia S. Morais*

BioMetals, 2021, 34, 1029. DOI: 10.1007/s10534-021-00325-w

29. Emerging molecular receptors for the specific-target delivery of ruthenium and gold complexes into cancer cells

João Franco Machado, João D. G. Correia, Tânia S. Morais*

Molecules, 2021, 26(11), 3153. DOI: 10.3390/molecules26113153


28. Bioconjugate supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo

Ben Woods Rúben D. M. Silva, Claudia Schmidt, Darren Wragg, Marco Cavaco, Vera F. C. Ferreira, Lurdes Gano, Tânia S. Morais, Filipa Mendes, João D. G. Correia, Angela Casini

Bioconjugate Chem., 2021, 32(7), 1399–1408. DOI: 10.1021/acs.bioconjchem.0c00659.


27. Cu(I) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: Synthesis, Characterization, and Mechanisms of Action

Diogo Sequeira, Pedro V. Baptista, Ruben Valente, M. Fátima M. Piedade, M. Helena Garcia, Tânia S. Morais*, Alexandra R. Fernandes*

Dalton Trans., 2021, 50, 1845-1865. DOI: 10.1039/D0DT03566A



 3. New Ruthenium(II) Mixed Metallocene derived complexes: Synthesis, Characterization by X-ray Diffraction Studies and Evaluation on DNA interaction by Atomic Force Microcopy

M. Helena Garcia, Andreia Valente, Pedro Florindo, Tânia S. Morais, M. Fátima M. Piedade, M. Teresa Duarte, Virtudes Moreno, Inorg. Chim. Acta, 2010, 363, 3765- 3775. DOI: 10.1016/j.ica.2010.05.034

 2. Studies of the Antiproliferative Activity of Ruthenium(II) Cyclopentadienyl derived Complexes with Nitrogen Coordinated Ligands

Virtudes Moreno, Julia Lorenzo, Francesc X. Avilés, M. Helena Garcia, João Ribeiro, Tânia S. Morais, Pedro Florindo

Bioinorg. Chem. App., 2010, article ID 936834. DOI: 10.1155/2010/396834           

 4. DNA interaction and cytotocixity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands

M. Helena Garcia, Tânia S. Morais, Andreia Valente, M. Paula Robalo, Mercè Font-Bardia, Teresa Calvet, Julia Lorenzo, Francesc X. Avilés

J. Inorg. Biochem., 2011, 105, 241-249. DOI: 10.1016/j.jinorgbio.2010.10.009


  8. [RuII(h5-C5H5)(bipy)(PPh3)]+ a promising large spectrum antitumor agent: cytotoxic activity and interaction with human sérum albumin

Ana Isabel Tomaz, Tamás Jakush, Tânia S. Morais, Fernanda Marques, Rodrigo F. M. de Almeida, Filipa Mendes, Éva A. Enyedy, Isabel Santos, João Costa Pessoa, Tamás Kiss, M. Helena Garcia

J. Inorg. Biochem., 2012,  117, 261 – 269. DOI: 10.1016/j.jinorgbio. 2012.06.016

  7. Gas-phase behaviour of Ru(II) cyclopentadienyl-derived complexes with N coordinated ligands by electrospray ionization mass spectrometry: fragmentation pathways and energetics

Paulo J. Amorim Madeira§, Tânia S. Morais§, Tiago Silva, Pedro Florindo, M. Helena Garcia

Rapid Comm. Mass Spectrom., 2012, 26, 1675-1686. DOI: 10.1002/rcm.6276. (§ both authors contributed equally to the work)

  6. Synthesis and structural characterization of new piano-stool ruthenium(II) complexes bearing 1-butylimidazole heteroaromatic ligand

Tânia S. Morais, M. Helena Garcia, M. Paula Robalo, M. Fátima M. Piedade, M. Teresa Duarte, M. José Villa de Brito, Paulo J. Amorim Madeira

J. Organomet.Chem., 2012, 712, 112- 122. DOI: 10.1016/j.jorganchem.2012.04.024

  5. Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines

Tânia S. Morais, Tiago J. L. Silva, Fernanda Marques, M. Paula Robalo, Fernando Avecilla, Paulo J. Amorim Madeira, Paulo J. G. Mendes, Isabel Santos, M. Helena Garcia

J. Inorg. Biochem., 2012, 114, 65-74. DOI: 10.1016/j.jinorgbio.2012.04.014


13. Exploring the effect of the ligand design on the interactions between [Ru(h5-C5H5)(PPh3)(N,O)][CF3SO3] complexes and Human Serum Albumin

Tânia S. Morais, Filipa C. Santos, Leonor Côrte-Real, M. Helena Garcia

J. Inorg. Biochem., 2013, 129, 94 - 101. DOI: 10.1016/ j.jinorgbio. 2013.09.008

12. Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands

Ana Cristina Gonçalves, Tânia S. Morais, M. Paula Robalo, Fernanda Marques, Fernando Avecilla, Cristina P. Matos, Isabel Santos, Ana Isabel Tomaz, M. Helena Garcia

J. Inorg. Biochem., 2013, 129, 1 - 8. DOI: 10.1016/j.jinorgbio. 2013.07.033

11. Synthesis, structural characterization and leishmanicidal activity evaluation of ferroncenyl N-hterocyclic compounds

Susana Quintal, Tânia S. Morais, Cristina P. Matos, M. Paula Robalo, M. Fátima M. Piedade, Maria J. Villa de Brito, M. Helena Garcia, Mónica Marques, Carla Maia, Lenea Campino, João Madureira

J. Organomet. Chem., 2013, 745-746, 299-311. DOI: 10.1016j/jorganchem. 2013.07.044

10. Cellular Uptake Mechanisms of na Antitumor Ruthenium compound: The endossomal/Lysosomal System as a Target for Anticancer Metal-Based Drugs

Leonor Côrte-Real, António P. Matos, Irina Alho, Tânia S. Morais, Ana Isabel Tomaz, Maria Helena Garcia, Isabel Santos, Manuel P. Bicho, Fernanda Marques

Microscopy and Microanalysis, 2013, 1-9. DOI: 10.1017/S143192761300175X

  9. Biological activity and cellular uptake of [Ru(h5-C5H5)(PPh3)(Me2bpy)][CF3SO3]

Tânia S. Morais, Filipa C. Santos, Leonor Côrte-Real, Fernanda Marques, M. Paula Robalo, Paulo J. Amorim Madeira, M. Helena Garcia

J. Inorg. Biochem., 2013, 122, 8-17. DOI: 10.1016j/jinorgbio.2013.01.011


15. Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes

Leonor Côrte-Real, Filipa Mendes, Joana Coimbra, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, Maria Helena Garcia, Isabel Santos, Manuel P. Bicho, Fernanda Marques

J. Biol. Inorg. Chem., 2014, 19, 853-867. DOI: 10.1007/s00775-014-1120-y

14. New Water-soluble Ruthenium(II) Cytotoxic Complex: Biological Activity and Cellular Distribution

Tânia S. Morais, Filipa C. Santos, Tiago F. Jorge, Leonor Côrte-Real, Paulo J. A. Madeira, Fernanda Marques, M. Paula Robalo, António Matos, Isabel Santos, M. Helena Garcia

J. Inorg. Biochem., 2014, 130, 1 - 14. DOI: 10.1016/ j.jinorgbio. 2013.09.013


17. Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasite

Mariana Fernández, Esteban Rodríguez Arce, Cynthia Sarniguet, Tânia S. Morais, Ana Isabel Tomaz, Claudio Olea Azar, Roberto Figueroa, J. Diego Maya, Andrea Medeiros, Marcelo Comini, M. Helena Garcia, Lucía Otero, Dinorah Gambino

J. Inorg. Biochem., 2015, 153, 306-314. DOI: 10.1016/j.jinorgbio.2015.06.0 18.

16. A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites

Esteban Rodrígues Arce, Cynthia Sarniguet, Tânia S. Morais, Marisol Vieites, Ana Isabel Tomaz, Andrea Medeiros, Marcelo Comini, Javier Varela, Hugo Cerecetto, Mercedes González, Fernanda Marques, M. Helena Garcia, Lucía Otero, Dinorah Gambino 

J. Coord. Chem., 2015, 68, 2923-2937. DOI: 10.1080/00958972.2015.1062480


18. Tracking antitumor metallodrugs: promising agents with the Ru(II)and Fe(II)cyclopentadienyl scaffolds

Tânia S. Morais, Andreia Valente, A. Isabel Tomaz, Fernanda Marques, M. Helena Garcia

Future Med. Chem., 2016, 8(5), 527-544. DOI: 10.4155/fmc.16.7.


20. New copper(I) and heteronuclear copper(I)–ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity

João Lopes, David Alves, Tânia S. Morais*, Paulo J. Costa, M. Fátima M. Piedade, Fernanda Marques, Maria J. Villa de Brito*, M. Helena Garcia

J. Inorg. Biochem., 2017, 169, 68-78. DOI: 10.1016/j.jinorgbio.2017.01.007

19. In vivo performance of a ruthenium cyclopentadienyl compound in an orthotopic triple negative breast cancer model

Nuno Mendes, Francisco Tortosa, António Matos, Fernanda Marques, Tânia S. Morais, Andreia Valente, Ana Isabel Tomaz, Fátima Gartner, M. Helena Garcia

Anti-Cancer Agents in Med. Chem., 2017, 17(1), 126 - 136. DOI: 10.2174/1871520616666160922165133


21. Important cytotoxic and cytostatic effects of new Copper(I)-phosphane compounds with NN, NO and NS bidentate ligands

Tânia S. Morais*, Yann Jousseaume, M. Fátima M. Piedade, Catarina Roma-Rodrigues, Alexandra R. Fernandes, Fernanda Marques, Maria J. Villa de Brito, M. Helena Garcia

Dalton Trans., 2018, 47, 7819-7829. DOI: 10.1039/C8DT01653D


23. First heterobimetallic Cu(I)−dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity

Catarina Bravo, Maria Paula Alves Robalo, Fernanda M. Marques, Alexandra R Fernandes, Diogo A. Sequeira, Maria Fátima Minas da Piedade, Maria Helena Garcia, Maria Villa Brito, Tânia S. Morais*

New J. of Chem., 2019, 43, 12308-12317. DOI: 10.1039/C9NJ02068C     

22. Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools

Lurdes Gano, Teresa Pinheiro, António Pedro Matos, Francisco Tortosa, Tiago F. Jorge, Maria Salomé Gonçalves, Tânia S. Morais, Andreia Valente, Ana Isabel Tomaz, Maria Helena Garcia, Fernanda Marques

Anti-Cancer Agents in Med. Chem., 2019, 19, 1262-1275. DOI: 10.2174/1871520619666190318152726


  1. Inhibition of Cancer Cell Growth by Ruthenium(II) Cycplopentadienyl derivative Complexes with Heteroaromatic Ligands

M. Helena Garcia, Tânia S. Morais, Pedro Florindo, M. Fátima M. Piedade, Virtudes Moreno, Carlos Ciudad, Veronica Noe

J. Inorg. Biochem., 2009, 103, 354-361. DOI: 10.1016/j.jinorgbio. 2008.11.016

© 2020 by Tânia Morais.
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